SEMA4A Polyclonal Antibody

SEMA4A

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

0.8 mg/mL

Unconjugated

IHC 1:30-1:150

Recombinant protein of human SEMA4A

Affinity purification

CORD10;RP11 54H19 2;RP35;SEM4A;Sema B;Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain 4A;Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4A;Sema domain;immunoglobulin domain (Ig);transmembrane domain (TM) and short cytoplasmic domain;(semaphorin);Sema4a;SEMAB;Semaphorin 4A precursor;Semaphorin B;Semaphorin-4A;Semaphorin-B;SEMB

Q9H3S1