SCN1A Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-16049-20uL | 20uL | £125.00 |
Quantity:
| E-AB-16049-60uL | 60uL | £172.00 |
Quantity:
| E-AB-16049-120uL | 120uL | £237.00 |
Quantity:
| E-AB-16049-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
SCN1A/2A/3A/4A/5A/8A/9A/10A/11A/13A
Background:
Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.5 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Synthetic peptide of human SCN1A/2A/3A/4A/5A/8A/9A/10A/11A/13A
Purification method:
Affinity purification
Target Synonym:
brain sodium channel type I;EIEE6;FEB3;FEB3A;FHM3;GEFS+2;GEFSP2;HBSC I;HBSCI;NAC1;Nav 1.1;RBI;SCN1;Scn1a;SCN1A;SMEI;Sodium channel protein brain I alpha subunit;Sodium channel protein brain I subunit alpha;Sodium channel protein type 1 subunit alpha;Sodium channel protein type I subunit alpha;Sodium channel voltage gated type 1 alpha subunit;Sodium channel voltage gated type I alpha polypeptide;Voltage-gated sodium channel subunit alpha Nav1.1
UNIProt ID:
P35498