RYR2 Polyclonal Antibody

RyR-2

This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.RYR2 (Ryanodine Receptor 2) is a Protein Coding gene. Diseases associated with RYR2 include Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 and Arrhythmogenic Right Ventricular Dysplasia 2. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cell-type Dependent Selectivity of CCK2R Signaling. GO annotations related to this gene include calcium ion binding and protein kinase binding. An important paralog of this gene is RYR3.

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

564kDa

1mg/mL

Unconjugated

WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000

Synthesized peptide derived from human RyR-2 around the non-phosphorylation site of Ser2808.

200-300kDa

Affinity purification

ARVC2;ARVD2;Cardiac muscle ryanodine receptor;Cardiac muscle ryanodine receptor-calcium release channel;hRYR-2;ryanodine receptor 2 (cardiac);Ryanodine receptor 2;RyR;RYR-2;RyR2;RYR2;Type 2 ryanodine receptor;VTSIP

Q92736