PTAFR Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-16022-20uL | 20uL | £125.00 |
Quantity:
| E-AB-16022-60uL | 60uL | £172.00 |
Quantity:
| E-AB-16022-120uL | 120uL | £237.00 |
Quantity:
| E-AB-16022-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
PTAFR
Background:
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.5 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:25-1:100
Immunogen:
Synthetic peptide of human PTAFR
Purification method:
Affinity purification
Target Synonym:
OTTHUMP00000004041;OTTMUSP00000010350;PAF R;PAF receptor;PAF-R;PAFr;Platelet activating factor receptor;Platelet-activating factor receptor;PTAFR;PTAFR;RP23-470B20.1
UNIProt ID:
P25105