PRMT5 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-12625-20uL | 20uL | £125.00 |
Quantity:
| E-AB-12625-60uL | 60uL | £172.00 |
Quantity:
| E-AB-12625-120uL | 120uL | £237.00 |
Quantity:
| E-AB-12625-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
PRMT5
Background:
Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
71kDa
Concentration:
0.3 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:200-1:1000
Immunogen:
Synthetic peptide of human PRMT5
Purification method:
Affinity purification
Target Synonym:
72 kDa ICln binding protein;72 kDa ICln-binding protein;ANM5;Histone synthetic lethal 7;S. cerevisiae;homolog of;Histone-arginine N-methyltransferase PRMT5;HMT1 hnRNP methyltransferase like 5;HOMOLOG OF;SKB1;HRMT1L5;IBP72;Jak-binding protein 1;JBP 1;JBP1;PRMT 5;PRMT5;Protein arginine methyltransferase 5;Protein arginine N methyltransferase 5;Protein arginine N methyltransferase 5 N terminally processed;Protein arginine N-methyltransferase 5;S. POMBE;S. POMBE HOMOLOG OF;SKB1;SHK1 KINASE BINDING PROTEIN 1;Shk1 kinase binding protein 1 homolog;Shk1 kinase-binding protein 1 homolog;Shk1 kinase/binding protein 1;S. pombe;homolog of;SKB 1;SKB1;SKB1 homolog;SKB1: SKB1 homolog (S. pombe);SKB1Hs
UNIProt ID:
O14744