PPP1R12A Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-11418-20uL | 20uL | £125.00 |
Quantity:
| E-AB-11418-60uL | 60uL | £172.00 |
Quantity:
| E-AB-11418-120uL | 120uL | £237.00 |
Quantity:
| E-AB-11418-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
PPP1R12A
Background:
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
115kDa
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:200-1:1000
Immunogen:
Recombinant protein of human PPP1R12A
Purification method:
Affinity purification
Target Synonym:
M130;MBS;Myosin binding subunit;Myosin phosphatase target subunit 1;Myosin phosphatase targeting subunit 1;Myosin phosphatase-targeting subunit 1;MYPT1;MYPT1;PPP1R12A;Protein phosphatase 1 regulatory inhibitor subunit 12A;Protein phosphatase 1 regulatory subunit 12A;Protein phosphatase 1;regulatory (inhibitor) subunit 12A;Protein phosphatase myosin binding subunit;Protein phosphatase myosin-binding subunit
UNIProt ID:
O14974
References
- https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.8b01023