Phospho-P38 (Thr180/Tyr182) Polyclonal Antibody

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Elabscience
Product Code: E-AB-21027
Product Group: Primary Antibodies
Supplier: Elabscience
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E-AB-21027-20uL20uL£125.00
Quantity:
E-AB-21027-60uL60uL£172.00
Quantity:
E-AB-21027-120uL120uL£237.00
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E-AB-21027-200uL200uL£344.00
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C

Images

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Immunohistochemistry of paraffin-embedded Human colon tissue with Phospho-p38 (Thr180/Tyr182) Polyclonal Antibody at dilution of 1:200
2 / 2
Immunofluorescence analysis of Mouse liver tissue with Phospho-p38 (Thr180/Tyr182) Polyclonal Antibody at dilution of 1:200
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Immunohistochemistry of paraffin-embedded Human colon tissue with Phospho-p38 (Thr180/Tyr182) Polyclonal Antibody at dilution of 1:200
Immunofluorescence analysis of Mouse liver tissue with Phospho-p38 (Thr180/Tyr182) Polyclonal Antibody at dilution of 1:200

Documents

Further Information

Abbreviation:
p38 (phospho Thr180/Tyr182)
Background:
MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EXIP,Mxi2,CSBP2,PRKM14,PRKM15,CSPB1,p38ALPHA and belongs to the MAP kinase subfamily. MAPK14-signaling is a central pathway for the integration of instructive signals in dendritic cells for T(H)17 differentiation and inflammation(PMID:22231518). It plays an important role in the regulation of hematopoietic stem cellself-renewal in vitro and inhibition of MAPK14 activation with a small molecule inhibitor may represent a novel approach to promote ex vivo expansion of hematopoietic stem cell(PMID:21198398). This protein has 4 isoforms produced by alternative splicing.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
41kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:5000
Immunogen:
Synthesized peptide derived from human p38 around the phosphorylation site of Thr180/Tyr182
ObservedMW:
38kDa
Purification method:
Affinity purification
Target Synonym:
CSAID Binding Protein 1;CSAID binding protein;CSAID-binding protein;Csaids binding protein;CSBP 1;CSBP 2;CSBP;CSBP1;CSBP2;CSPB1;Cytokine suppressive anti-inflammatory drug-binding protein;EXIP;MAP kinase 14;MAP kinase MXI2;MAP kinase p38 alpha;MAPK 14;MAPK14;MAX interacting protein 2;MAX-interacting protein 2;Mitogen Activated Protein Kinase 14;Mitogen activated protein kinase p38 alpha;Mitogen-activated protein kinase 14;Mitogen-activated protein kinase p38 alpha;MK14;Mxi 2;MXI2;p38 ALPHA;p38;p38 MAP kinase;p38 MAPK;p38 mitogen activated protein kinase;p38ALPHA;p38alpha Exip;PRKM14;PRKM15;RK;SAPK2A
UNIProt ID:
Q16539

References

  • https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-023-01803-8
  • https://onlinelibrary.wiley.com/doi/abs/10.1111/cpr.13351
  • https://www.sciencedirect.com/science/article/pii/S0753332223000823
  • https://www.mdpi.com/1281194
  • https://link.springer.com/article/10.1007/s12079-022-00703-0
  • https://link.springer.com/article/10.1186/s12935-022-02503-3
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364650/
  • https://www.mdpi.com/2076-3921/9/1/37/htm
  • https://pubs.acs.org/doi/abs/10.1021/acs.jafc.8b07227
  • https://www.sciencedirect.com/science/article/pii/S1567576918312372
  • https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14041
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201345/