Phospho-FAK (Tyr397) Polyclonal Antibody

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Elabscience
Product Code: E-AB-21207
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-21207-20uL20uL£125.00
Quantity:
E-AB-21207-60uL60uL£172.00
Quantity:
E-AB-21207-120uL120uL£237.00
Quantity:
E-AB-21207-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C

Images

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Western Blot analysis of 293T cells with Phospho-FAK (Tyr397) Polyclonal Antibody at dilution of 1:1000
2 / 2
Immunohistochemistry of paraffin-embedded Human stomach cancer tissue with Phospho-FAK (Tyr397) Polyclonal Antibody at dilution of 1:200
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Western Blot analysis of 293T cells with Phospho-FAK (Tyr397) Polyclonal Antibody at dilution of 1:1000
Immunohistochemistry of paraffin-embedded Human stomach cancer tissue with Phospho-FAK (Tyr397) Polyclonal Antibody at dilution of 1:200

Documents

Further Information

Abbreviation:
FAK (phospho Tyr397)
Background:
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
119kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Immunogen:
Synthesized peptide derived from human FAK around the phosphorylation site of Tyr397
ObservedMW:
119kDa
Purification method:
Affinity purification
Target Synonym:
FADK 1;FADK;FAK related non kinase polypeptide;FAK1;FAK1;Focal adhesion kinase 1;Focal adhesion Kinase;Focal adhesion kinase isoform FAK Del33;Focal adhesion kinase related nonkinase;FRNK;p125FAK;pp125FAK;PPP1R71;Protein phosphatase 1 regulatory subunit 71;Protein tyrosine kinase 2;Protein-tyrosine kinase 2;Ptk2;PTK2 protein tyrosine kinase 2
UNIProt ID:
Q05397

References

  • https://www.mdpi.com/955494