Phospho-Catenin beta (Tyr654) Polyclonal Antibody

Catenin-β (phospho Tyr654)

Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

85kDa

1 mg/mL

Unconjugated

WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000

Synthesized peptide derived from human Catenin-β around the phosphorylation site of Tyr654

75kDa

Affinity purification

Beta catenin;Beta-catenin;Cadherin associated protein;Catenin (cadherin associated protein);beta 1;88kDa;Catenin beta 1;Catenin beta-1;CATNB;CHBCAT;CTNB1;CTNNB;CTNNB1;DKFZp686D02253;FLJ25606;FLJ37923;OTTHUMP00000162082;OTTHUMP00000165222;OTTHUMP00000165223;OTTHUMP00000209288;OTTHUMP00000209289

P35222