PDGFB Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-16031-20uL | 20uL | £125.00 |
Quantity:
| E-AB-16031-60uL | 60uL | £172.00 |
Quantity:
| E-AB-16031-120uL | 120uL | £237.00 |
Quantity:
| E-AB-16031-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
PDGFB
Background:
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Synthetic peptide of human PDGFB
Purification method:
Affinity purification
Target Synonym:
Becaplermin;PDGF 2;PDGF B chain;PDGF subunit B;PDGF-2;PDGF2;Pdgfb;PDGFB;Platelet derived growth factor 2;Platelet-derived growth factor B chain;Platelet-derived growth factor beta polypeptide;Platelet-derived growth factor subunit B;Proto-oncogene c-Sis;SIS;SSV
UNIProt ID:
P01127