P38 Polyclonal Antibody

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Elabscience
Product Code: E-AB-32461
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-32461-20uL20uL£125.00
Quantity:
E-AB-32461-60uL60uL£172.00
Quantity:
E-AB-32461-120uL120uL£237.00
Quantity:
E-AB-32461-200uL200uL£344.00
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Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C

Images

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Western Blot analysis of Hela cells using p38 Polyclonal Antibody at dilution of 1:1000.
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Western Blot analysis of Hela cells using p38 Polyclonal Antibody at dilution of 1:1000.

Documents

Further Information

Abbreviation:
p38
Background:
Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
41kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
Immunogen:
Synthesized peptide derived from human p38 around the non-phosphorylation site of Tyr323.
ObservedMW:
38kDa
Purification method:
Affinity purification
Target Synonym:
CSAID Binding Protein 1;CSAID binding protein;CSAID-binding protein;Csaids binding protein;CSBP 1;CSBP 2;CSBP;CSBP1;CSBP2;CSPB1;Cytokine suppressive anti-inflammatory drug-binding protein;EXIP;MAP kinase 14;MAP kinase MXI2;MAP kinase p38 alpha;MAPK 14;MAPK14;MAX interacting protein 2;MAX-interacting protein 2;Mitogen Activated Protein Kinase 14;Mitogen activated protein kinase p38 alpha;Mitogen-activated protein kinase 14;Mitogen-activated protein kinase p38 alpha;MK14;Mxi 2;MXI2;p38 ALPHA;p38;p38 MAP kinase;p38 MAPK;p38 mitogen activated protein kinase;p38ALPHA;p38alpha Exip;PRKM14;PRKM15;RK;SAPK2A
UNIProt ID:
Q16539

References

  • https://www.nature.com/articles/s41419-022-05416-1
  • https://www.mdpi.com/1422-0067/23/23/14657
  • https://link.springer.com/article/10.1007/s12035-019-1493-6
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364650/
  • https://www.frontiersin.org/articles/10.3389/fphys.2020.00403/full?report=reader
  • https://www.sciencedirect.com/science/article/pii/S1567576918312372
  • https://onlinelibrary.wiley.com/doi/abs/10.1111/nep.12831
  • https://www.koreascience.or.kr/article/JAKO202025164428524.page