NUAK1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-16173-20uL | 20uL | £125.00 |
Quantity:
| E-AB-16173-60uL | 60uL | £172.00 |
Quantity:
| E-AB-16173-120uL | 120uL | £237.00 |
Quantity:
| E-AB-16173-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
NUAK1
Background:
NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
1.4 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:100-1:300
Immunogen:
Synthetic peptide of human NUAK1
Purification method:
Affinity purification
Target Synonym:
AMP activated protein kinase family member 5;AMPK related protein kinase 5;AMPK-related protein kinase 5;NUAK family SNF1 like kinase;NUAK family SNF1-like kinase 1;Nuak1;NUAK1;Omphalocele kinase 1;Probable serine/threonine protein kinase KIAA0537
UNIProt ID:
O60285