NPRL2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-16658-20uL | 20uL | £125.00 |
Quantity:
| E-AB-16658-60uL | 60uL | £172.00 |
Quantity:
| E-AB-16658-120uL | 120uL | £237.00 |
Quantity:
| E-AB-16658-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
NPRL2
Background:
NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.9 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Synthetic peptide of human NPRL2
Purification method:
Affinity purification
Target Synonym:
2810446G01Rik;G21 protein;Gene 21 protein;Homologous to yeast nitrogen permease (candidate tumor suppressor);Homologous to yeast nitrogen permease;Nitrogen permease regulator 2-like protein;Nitrogen permease regulator-like 2 (S. cerevisiae);NPR 2L;NPR L2;NPR like 2;NPR2;NPR2 like;NPR2-like protein;NPR2L;NPRL 2;NPRL2;NPRL2;Tumor suppressor candidate 4;TUSC 4;TUSC 4 protein;TUSC4;TUSC4 protein
UNIProt ID:
Q8WTW4