NPR1 Polyclonal Antibody

NPR1

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms . The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

0.4 mg/mL

Unconjugated

IHC 1:25-1:100

Synthetic peptide of human NPR1

Affinity purification

ANP-A;ANPa;ANPR-A;ANPRA;ANPRA;Atrial natriuretic peptide A type receptor;Atrial natriuretic peptide receptor 1;Atrial natriuretic peptide receptor A;Atrial natriuretic peptide receptor type A;Atrionatriuretic peptide receptor A;GC A;GC-A;Guanylate cyclase A;Guanylate cyclase;GUC2A;GUCY2A;Natriuretic peptide A type receptor;Natriuretic peptide receptor A/guanylate cyclase A;NPR-A;NPR1;NPRA

P16066