NOTCH1 Polyclonal Antibody

Contact us
Elabscience
Product Code: E-AB-12815
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-12815-20uL20uL£125.00
Quantity:
E-AB-12815-60uL60uL£172.00
Quantity:
E-AB-12815-120uL120uL£237.00
Quantity:
E-AB-12815-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C

Images

1 / 2
Western Blot analysis of HT-29 cell using NOTCH1 Polyclonal Antibody at dilution of 1:600
2 / 2
Immunohistochemistry of paraffin-embedded Rat lung using NOTCH1 Polyclonal Antibody at dilution of 1:50
❮❯

Western Blot analysis of HT-29 cell using NOTCH1 Polyclonal Antibody at dilution of 1:600
Immunohistochemistry of paraffin-embedded Rat lung using NOTCH1 Polyclonal Antibody at dilution of 1:50

Documents

Further Information

Abbreviation:
NOTCH1
Background:
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
273kDa
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200
Immunogen:
Synthetic peptide of human NOTCH1
Purification method:
Affinity purification
Target Synonym:
hN1;Neurogenic locus Notch homolog protein 1;NICD;NOTC1;Notch 1;Notch 1 intracellular domain;Notch homolog 1 translocation associated (Drosophila);notch1;TAN1;Translocation-associated notch protein TAN-1
UNIProt ID:
P46531

References

  • https://academic.oup.com/humrep/article-abstract/37/Supplement_1/deac104.075/6620257
  • https://www.mdpi.com/1948780
  • https://journals.sagepub.com/doi/abs/10.1177/1545968320925474
  • https://onlinelibrary.wiley.com/doi/abs/10.1111/and.13413