MRE11 Polyclonal Antibody
Code | Size | Price |
---|
E-AB-11403-20uL | 20uL | £125.00 |
Quantity:
E-AB-11403-60uL | 60uL | £172.00 |
Quantity:
E-AB-11403-120uL | 120uL | £237.00 |
Quantity:
E-AB-11403-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Images
Further Information
Abbreviation:
MRE11A
Background:
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
81kDa
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300
Immunogen:
Recombinant protein of human MRE11A
Purification method:
Affinity purification
Target Synonym:
AT like disease;Ataxia telangiectasia disorder like;ATLD;DNA recombination and repair protein;Double strand break repair protein MRE11A;Double-strand break repair protein MRE11A;endo/exonuclease Mre11;HNGS1;meiotic recombination (S. cerevisiae) 11 homolog A;Meiotic recombination 11 homolog 1;meiotic recombination 11 homolog A (S. cerevisiae);Meiotic recombination 11 homolog A;MmMRE11A;Mre 11;MRE 11a;MRE 11b;MRE11 homolog 1;MRE11 homolog A;MRE11 homolog double strand break repair nuclease;MRE11 meiotic recombination 11 homolog A (S. cerevisiae);MRE11 meiotic recombination 11 homolog A;MRE11;MRE11A;MRE11b;OTTHUMP00000236830;OTTHUMP00000236831;OTTHUMP00000236832;OTTHUMP00000236833
UNIProt ID:
P49959
References
- https://www.nature.com/articles/s41467-021-26293-w
- https://www.tandfonline.com/doi/abs/10.1080/15384047.2021.2020060