MMP2 Polyclonal Antibody

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Elabscience
Product Code: E-AB-32054
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-32054-20uL20uL£125.00
Quantity:
E-AB-32054-60uL60uL£172.00
Quantity:
E-AB-32054-120uL120uL£237.00
Quantity:
E-AB-32054-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Monkey
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C

Images

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Immunohistochemistry of paraffin-embedded Human liver cancer tissue using MMP2 Polyclonal Antibody at dilution of 1:200.
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Immunohistochemistry of paraffin-embedded Human liver cancer tissue using MMP2 Polyclonal Antibody at dilution of 1:200.

Documents

Further Information

Abbreviation:
MMP-2
Background:
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro.PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
74kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
Immunogen:
Synthesized peptide derived from the C-terminal region of human MMP-2
ObservedMW:
74kDa
Purification method:
Affinity purification
Target Synonym:
72 kDa gelatinase;72kD type IV collagenase;CLG 4;CLG 4A;CLG4;CLG4A;Collagenase Type 4 alpha;Collagenase type IV A;Gelatinase A;Gelatinase alpha;Gelatinase neutrophil;Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase;Matrix metalloproteinase 2 (gelatinase A;72kDa gelatinase;72kDa type IV collagenase);Matrix Metalloproteinase 2;Matrix metalloproteinase II;Matrix metalloproteinase-2;MMP 2;MMP II;MMP-2;MMP2;MMP2;MONA;Neutrophil gelatinase;PEX;TBE 1;TBE-1
UNIProt ID:
P08253

References

  • https://link.springer.com/article/10.1007/s11655-018-2985-3