MDC1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-12802-20uL | 20uL | £125.00 |
Quantity:
| E-AB-12802-60uL | 60uL | £172.00 |
Quantity:
| E-AB-12802-120uL | 120uL | £237.00 |
Quantity:
| E-AB-12802-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
MDC1
Background:
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
1.2 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:100-1:300
Immunogen:
Synthetic peptide of human MDC1
Purification method:
Affinity purification
Target Synonym:
Homologue to Drosophila photoreceptor protein calphotin;MDC 1;Mdc1;MDC1;Mediation of DNA damage checkpoint 1;Mediator of DNA damage checkpoint 1;Mediator of DNA damage checkpoint protein 1;NFBD 1;NFBD1;Nuclear factor with BRCT domains 1;Nuclear Factor with BRCT Domains Protein 1
UNIProt ID:
Q14676