MCM4 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-15771-20uL | 20uL | £125.00 |
Quantity:
| E-AB-15771-60uL | 60uL | £172.00 |
Quantity:
| E-AB-15771-120uL | 120uL | £237.00 |
Quantity:
| E-AB-15771-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
MCM4
Background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
97kDa
Concentration:
0.3 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200
Immunogen:
Synthetic peptide of human MCM4
Purification method:
Affinity purification
Target Synonym:
19G;AI325074;AU045576;CDC 21;CDC 54;CDC21;CDC21 homolog;CDC21;S. pombe;homolog of;CDC54;Cell division cycle 21;S. pombe;homolog of;DNA replication licensing factor MCM 4;DNA replication licensing factor MCM4;hCdc 21;hCdc21;Homolog of S. pombe cell devision cycle 21;KIAA4003;mcdc21;MCM 4;MCM 4 minichromosome maintenance deficient 4;mcm4;MCM4 minichromosome maintenance deficient 4;MCM4 minichromosome maintenance deficient 4;mitotin (S. cerevisiae);MCM4;Mcmd4;MGC33310;Minichromosome maintenance 4;Minichromosome maintenance complex component 4;Minichromosome maintenance deficient (S. cerevisiae) 4;Minichromosome maintenance deficient 4;Minichromosome maintenance deficient 4 homolog (S. cerevisiae);Minichromosome maintenance;S. cerevisiae;homolog of;4;mKIAA4003;NKCD;NKGCD;P1 CDC21;P1-CDC21;P1CDC21
UNIProt ID:
P33991