JNK1 Polyclonal Antibody
Code | Size | Price |
---|
E-AB-12525-20uL | 20uL | £125.00 |
Quantity:
E-AB-12525-60uL | 60uL | £172.00 |
Quantity:
E-AB-12525-120uL | 120uL | £237.00 |
Quantity:
E-AB-12525-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Images
Further Information
Abbreviation:
MAPK8
Background:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
48kDa
Concentration:
0.5 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200
Immunogen:
Synthetic peptide of human MAPK8
Purification method:
Affinity purification
Target Synonym:
AI849689;c Jun N terminal kinase 1;C-JUN kinase 1;c-Jun N-terminal kinase 1;EC 2.7.11.24;JNK 1;JNK;JNK-46;JNK1A2;JNK21B1/2;MAP kinase 8;MAPK 8;mapk8;Mitogen activated protein kinase 8;Mitogen-activated protein kinase 8;MK08;p54 gamma;Prkm8;Protein kinase JNK1;Protein kinase;mitogen-activated;8;SAPK 1;SAPK gamma;SAPK1;Stress-activated protein kinase 1;Stress-activated protein kinase JNK1
UNIProt ID:
P45983
References
- https://link.springer.com/article/10.1007/s12079-022-00703-0
- https://www.frontiersin.org/articles/10.3389/fonc.2019.01469/full