LRP6 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-17347-20uL | 20uL | £125.00 |
Quantity:
| E-AB-17347-60uL | 60uL | £172.00 |
Quantity:
| E-AB-17347-120uL | 120uL | £237.00 |
Quantity:
| E-AB-17347-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
LRP6
Background:
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
1.4 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:40-200, ELISA 1:2000-10000
Immunogen:
Synthetic peptide of human LRP6
Purification method:
Affinity purification
Target Synonym:
ADCAD2;C030016K15Rik;Cd;FLJ90062;FLJ90421;LDL receptor related protein 6;Low density lipoprotein receptor related protein 6;Low-density lipoprotein receptor-related protein 6;LRP-6;LRP6;LRP6;OTTHUMP00000238979;OTTHUMP00000238980;OTTHUMP00000238982;STHAG7
UNIProt ID:
O75581
References
- https://www.frontiersin.org/articles/10.3389/fonc.2018.00470/full