KI67 Monoclonal Antibody

Ki 67

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

1 mg/mL

Unconjugated

IHC 1:100-1:300, IF 1:50-200

Synthetic Peptide

Protein A purification

Antigen identified by monoclonal Ki 67;Antigen identified by monoclonal Ki-67;Antigen KI-67;Antigen KI67;Antigen Ki67;KI67;KIA;Marker of proliferation Ki-67;MIB 1;MIB;MKI67;PPP1R105;Proliferation marker protein Ki-67;Proliferation related Ki 67 antigen;Protein phosphatase 1 regulatory subunit 105;RP11-380J17.2

P46013