KCNQ4 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-16544-20uL | 20uL | £125.00 |
Quantity:
| E-AB-16544-60uL | 60uL | £172.00 |
Quantity:
| E-AB-16544-120uL | 120uL | £237.00 |
Quantity:
| E-AB-16544-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
KCNQ4
Background:
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
77kDa
Concentration:
0.9 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:200-1:1000, IHC 1:50-1:200
Immunogen:
Synthetic peptide of human KCNQ4
Purification method:
Affinity purification
Target Synonym:
DFNA 2;DFNA2;KCNQ 4;Kcnq4;KCNQ4;KQT like 4;KQT-like 4;KV7.4;Potassium channel KQT like 4;Potassium channel subunit alpha KvLQT4;Potassium voltage gated channel KQT like protein 4;Potassium voltage gated channel KQT like subfamily member 4;Potassium voltage gated channel subfamily KQT member 4;Potassium voltage-gated channel subfamily KQT member 4;Voltage gated potassium channel subunit Kv7.4;Voltage-gated potassium channel subunit Kv7.4
UNIProt ID:
P56696
References
- https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14700