KCNJ11 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-11188-20uL | 20uL | £125.00 |
Quantity:
| E-AB-11188-60uL | 60uL | £172.00 |
Quantity:
| E-AB-11188-120uL | 120uL | £237.00 |
Quantity:
| E-AB-11188-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
KCNJ11
Background:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Recombinant protein of human KCNJ11
Purification method:
Affinity purification
Target Synonym:
ATP sensitive inward rectifier potassium channel 11;Beta cell inward rectifier subunit;BIR;HHF 2;HHF2;IKATP;Inward rectifier K(+) channel Kir6.2;Inwardly rectifying potassium channel KIR6.2;IRK 11;IRK11;KCNJ11;Kir 6.2;Kir6.2;MGC133230;PHHI;Potassium channel inwardly rectifing subfamily J member 11;Potassium channel;inwardly rectifying subfamily J member 11;Potassium inwardly rectifying channel J11;TNDM 3;TNDM3
UNIProt ID:
Q14654