IRAK1BP1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-10411-20uL | 20uL | £125.00 |
Quantity:
| E-AB-10411-60uL | 60uL | £172.00 |
Quantity:
| E-AB-10411-120uL | 120uL | £237.00 |
Quantity:
| E-AB-10411-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
IRAK1BP1
Background:
SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
29kDa
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200
Immunogen:
Recombinant protein of human IRAK1BP1
Purification method:
Affinity purification
Target Synonym:
ActA binding protein 3;AIP70;Interleukin 1 receptor associated kinase 1 binding protein 1;IRAK1-binding protein 1;Signaling molecule that associates with Pelle-like kinase;SIMPL
UNIProt ID:
Q5VVH5