IDE Monoclonal Antibody
| Code | Size | Price |
|---|
| E-AB-22041-20uL | 20uL | £125.00 |
Quantity:
| E-AB-22041-60uL | 60uL | £172.00 |
Quantity:
| E-AB-22041-120uL | 120uL | £237.00 |
Quantity:
| E-AB-22041-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: Clone:1H4
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
IDE
Background:
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.
Buffer:
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-300, IF 1:100-1:300
Immunogen:
Synthetic Peptide
ObservedMW:
118kDa
Purification method:
Protein A purification
Target Synonym:
Abeta-degrading protease;FLJ35968;Ide;IDE;Insulin protease;Insulin-degrading enzyme;Insulinase;Insulysin;OTTHUMP00000020097
UNIProt ID:
P14735