HSD11B2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-13311-20uL | 20uL | £125.00 |
Quantity:
| E-AB-13311-60uL | 60uL | £172.00 |
Quantity:
| E-AB-13311-120uL | 120uL | £237.00 |
Quantity:
| E-AB-13311-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
HSD11B2
Background:
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Synthetic peptide of human HSD11B2
Purification method:
Affinity purification
Target Synonym:
11 beta HSD2;11 beta hydroxysteroid dehydrogenase type 2;11 DH2;11-beta-HSD2;11-beta-hydroxysteroid dehydrogenase type 2;11-DH2;AME;AME1;Corticosteroid 11 beta dehydrogenase isozyme 2;Corticosteroid 11-beta-dehydrogenase isozyme 2;DHI2;HSD11B2;HSD11K;HSD2;Hydroxysteroid 11 beta dehydrogenase 2;Hydroxysteroid 11 beta dehydrogenase isoenzyme 2;NAD dependent 11 beta hydroxysteroid dehydrogenase;NAD-dependent 11-beta-hydroxysteroid dehydrogenase;SDR9C3;Short chain dehydrogenase/reductase family 9C;member 3
UNIProt ID:
P80365