HP Polyclonal Antibody

HP

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

45kDa

0.4 mg/mL

Unconjugated

WB 1:200-1:1000

Recombinant protein of human HP

Affinity purification

Binding peptide;BP;Haptoglobin alpha chain;Haptoglobin alpha(1S) beta;Haptoglobin alpha(2FS) beta;Haptoglobin beta chain;Haptoglobin;alpha polypeptide;Haptoglobin;beta polypeptide;HP;HP2 ALPHA2;HP2ALPHA2;HPA1S;HPT;HPT;MGC111141;Zonulin

P00738