HMGCS1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-13295-20uL | 20uL | £125.00 |
Quantity:
| E-AB-13295-60uL | 60uL | £172.00 |
Quantity:
| E-AB-13295-120uL | 120uL | £237.00 |
Quantity:
| E-AB-13295-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
HMGCS1
Background:
HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
57kDa
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200
Immunogen:
Synthetic peptide of human HMGCS1
Purification method:
Affinity purification
Target Synonym:
3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble);3-hydroxy-3-methylglutaryl coenzyme A synthase;cytoplasmic;EC 2.3.3.10;HMCS1;HMG CoA synthase;HMG-CoA synthase;HMGCS;HMGCS1;Hydroxymethylglutaryl CoA synthase;cytoplasmic;Hydroxymethylglutaryl-CoA synthase;MGC90332
UNIProt ID:
Q01581