HIF1AN Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-13556-20uL | 20uL | £125.00 |
Quantity:
| E-AB-13556-60uL | 60uL | £172.00 |
Quantity:
| E-AB-13556-120uL | 120uL | £237.00 |
Quantity:
| E-AB-13556-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
HIF1AN
Background:
Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1alpha. Specifically, FIH-1 operates as an asparaginyl hydroxylase. It catalyzes the hydroxylation of the beta-carbon of Asparagine residue 803 within the carboxy terminal transactivation domain of HIF-1alpha. This hydroxylation event blocks the association of HIF-1alpha with co-activators. FIH-1 also binds to von Hippel-Lindau (VHL) tumor suppressor protein, which represses transcriptional ac-tivity of HIF-1alpha. In transiently transfected human osteosarcoma cells, FIH-1 localizes to the cytoplasm.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
40kDa
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:300
Immunogen:
Synthetic peptide of human HIF1AN
Purification method:
Affinity purification
Target Synonym:
DKFZp762F1811;Factor inhibiting HIF-1;Factor inhibiting HIF1;FIH 1;FIH-1;FIH1;FLJ20615;FLJ22027 ;HIF1AN;HIF1N;Hypoxia inducible factor 1 alpha inhibitor;Hypoxia inducible factor 1 alpha subunit inhibitor;Hypoxia inducible factor asparagine hydroxylase;Hypoxia-inducible factor 1-alpha inhibitor;Hypoxia-inducible factor asparagine hydroxylase;Peptide aspartate beta dioxygenase
UNIProt ID:
Q9NWT6