GSK3 alpha Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-12494-20uL | 20uL | £125.00 |
Quantity:
| E-AB-12494-60uL | 60uL | £172.00 |
Quantity:
| E-AB-12494-120uL | 120uL | £237.00 |
Quantity:
| E-AB-12494-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
GSK3A
Background:
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Synthetic peptide of human GSK3A
Purification method:
Affinity purification
Target Synonym:
DKFZp686D0638;Glycogen synthase kinase 3 alpha;Glycogen synthase kinase-3 alpha;GSK 3 alpha;GSK 3A;GSK-3 alpha;Gsk3a;GSK3A;GSK3alpha;Serine/threonine protein kinase GSK3A
UNIProt ID:
P49840