GRM3 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-14110-20uL | 20uL | £125.00 |
Quantity:
| E-AB-14110-60uL | 60uL | £172.00 |
Quantity:
| E-AB-14110-120uL | 120uL | £237.00 |
Quantity:
| E-AB-14110-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
GRM3
Background:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.2 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Recombinant protein of human GRM3
Purification method:
Affinity purification
Target Synonym:
GLUR3;Glutamate metabotropic receptor 3;Glutamate receptor metabotropic 3;GPRC1C;GRM3;GRM3;Metabotropic glutamate receptor 3;MGlu3;mGluR3
UNIProt ID:
Q14832
References
- https://www.sciencedirect.com/science/article/pii/S0361923019307245