GJB6 Polyclonal Antibody

GJB6

Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

0.4 mg/mL

Unconjugated

IHC 1:25-1:100

Synthetic peptide of human GJB6

Affinity purification

Connexin 30;Connexin-30;Cx30;CXB6;DFNA3;DFNA3B;DFNB1B;ECTD2;ectodermal dysplasia 2;hidrotic (Clouston syndrome);ED2;EDH;Gap junction beta 6 protein;Gap junction beta-6 protein;gap junction protein;beta 6 (connexin 30);gap junction protein;beta 6;Gap junction protein;beta 6;30kDa;GJB6;HED;HED2;NSRD1

O95452