GCK Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-11261-20uL | 20uL | £125.00 |
Quantity:
| E-AB-11261-60uL | 60uL | £172.00 |
Quantity:
| E-AB-11261-120uL | 120uL | £237.00 |
Quantity:
| E-AB-11261-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
GCK
Background:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
52kDa
Concentration:
0.3 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200
Immunogen:
Recombinant protein of human GCK
Purification method:
Affinity purification
Target Synonym:
ATP:D-hexose 6-phosphotransferase;FGQTL3;GCK;GK;GLK;Glucokinase;Hexokinase D pancreatic isozyme;Hexokinase type IV;Hexokinase-4;Hexokinase-D;HHF3;HK IV;HK4;HKIV;HXK4;HXKP;LGLK;MODY2
UNIProt ID:
P35557