FZD6 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-12926-20uL | 20uL | £125.00 |
Quantity:
| E-AB-12926-60uL | 60uL | £172.00 |
Quantity:
| E-AB-12926-120uL | 120uL | £237.00 |
Quantity:
| E-AB-12926-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
FZD6
Background:
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.2 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:100-1:300
Immunogen:
Synthetic peptide of human FZD6
Purification method:
Affinity purification
Target Synonym:
Frizzled 6 seven transmembrane spanning receptor;Frizzled drosophila homolog of 6;Frizzled family receptor 6;Frizzled homolog 6 (Drosophila);Frizzled homolog 6;Frizzled-6;Frizzled6;Fz 6;Fz-6;Fz6;FZD 6;Fzd6;FZD6;Hfz 6;hFz6;NDNC10
UNIProt ID:
O60353