FGFR1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-10320-20uL | 20uL | £125.00 |
Quantity:
| E-AB-10320-60uL | 60uL | £172.00 |
Quantity:
| E-AB-10320-120uL | 120uL | £237.00 |
Quantity:
| E-AB-10320-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
FGFR1
Background:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:300
Immunogen:
Recombinant protein of human FGFR1
Purification method:
Affinity purification
Target Synonym:
Basic fibroblast growth factor receptor 1;bFGF-R-1;BFGFR;CD331;CEK;FGFBR;FGFR 1;FGFR-1;FGFR1;FGFR1/PLAG1 fusion;FGFR1;fibroblast growth factor receptor 1;FLG;FLT-2;FLT2;Fms-like gene;Fms-like tyrosine kinase 2;fms-related tyrosine kinase 2;HBGFR;heparin-binding growth factor receptor;HH2;HRTFDS;hydroxyaryl-protein kinase;KAL2;N-SAM;OGD;Proto-oncogene c-Fgr
UNIProt ID:
P11362