Factor XIIIa Polyclonal Antibody

F13A1

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

0.1 mg/mL

Unconjugated

IHC 1:100-1:300

Synthetic peptide of human F13A1

Affinity purification

bA525O21.1 (coagulation factor XIII;A1 polypeptide);Coagulation factor XIII A chain;Coagulation factor XIII A1 polypeptide;Coagulation factor XIII A1 subunit;Coagulation factor XIII;A polypeptide;Coagulation factor XIIIa;F13A;F13A;F13a1;Factor XIIIA;Fibrin stabilizing factor;A subunit;Fibrinoligase;FSF;A subunit;Protein glutamine gamma glutamyltransferase A chain;Protein-glutamine gamma-glutamyltransferase A chain;TGase;Transglutaminase A chain;Transglutaminase;plasma;Transglutaminase. plasma

P00488