ERN2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-16413-20uL | 20uL | £125.00 |
Quantity:
| E-AB-16413-60uL | 60uL | £172.00 |
Quantity:
| E-AB-16413-120uL | 120uL | £237.00 |
Quantity:
| E-AB-16413-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
ERN2
Background:
The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
1.1 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Synthetic peptide of human ERN2
Purification method:
Affinity purification
Target Synonym:
IRE1b;IRE1-BETA
UNIProt ID:
Q76MJ5