ERK 1/2 Polyclonal Antibody

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Elabscience
Product Code: E-AB-31374
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-31374-20uL20uL£125.00
Quantity:
E-AB-31374-60uL60uL£172.00
Quantity:
E-AB-31374-120uL120uL£237.00
Quantity:
E-AB-31374-200uL200uL£344.00
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Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C

Images

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Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ERK 1/2 Polyclonal Antibody at dilution of 1:200.
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Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ERK 1/2 Polyclonal Antibody at dilution of 1:200.

Documents

Further Information

Abbreviation:
ERK 1/2
Background:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
43kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:10000
Immunogen:
Synthesized peptide derived from the C-terminal region of human ERK 1/2
ObservedMW:
42,44kDa
Purification method:
Affinity purification
Target Synonym:
MAPK3;ERK1;PRKM3;Mitogen-activated protein kinase 3;MAP kinase 3;MAPK 3;ERT2;Extracellular signal-regulated kinase 1;ERK-1;Insulin-stimulated MAP2 kinase;MAP kinase isoform p44;p44-MAPK;Microtubule-associated protein 2 kinase;p
UNIProt ID:
P27361,P28482

References

  • https://www.mdpi.com/article/10.3390/cells12010115
  • https://www.mdpi.com/1492614
  • https://www.frontiersin.org/articles/10.3389/fphys.2020.00403/full?report=reader