ERG Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-14117-20uL | 20uL | £125.00 |
Quantity:
| E-AB-14117-60uL | 60uL | £172.00 |
Quantity:
| E-AB-14117-120uL | 120uL | £237.00 |
Quantity:
| E-AB-14117-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
ERG
Background:
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
54kDa
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200
Immunogen:
Recombinant protein of human ERG
Purification method:
Affinity purification
Target Synonym:
Avian erythroblastosis virus E-26 (v-ets) oncogene related;D030036I24Rik;Erg 3;Erg;ERG/EWS fusion gene;included;ERG/FUS fusion gene;included;ERG/TMPSSR2 fusion gene;included;ERG;ERG1;included;ERG2;included;ets related;ETS-related gene;KCNH2;Oncogene ERG;p55;TMPRSS2/ERG fusion;transcriptional regulator ERG (transforming protein ERG);Transcriptional regulator ERG;Transforming protein ERG;v ets avian erythroblastosis virus E26 oncogene;v ets avian erythroblastosis virus E26 oncogene related;v ets erythroblastosis virus E26 oncogene homolog;v ets erythroblastosis virus E26 oncogene like;v ets erythroblastosis virus E26 oncogene like isoform 2;v-ets erythroblastosis virus E26 oncogene;v-ets erythroblastosis virus E26 oncogene homolog (avian);V-ets erythroblastosis virus E26 oncogene like (Avian);isoform CRA_e
UNIProt ID:
P11308