ELP2 Polyclonal Antibody

ELP2

One member of the STAT family, Stat3, participates in a wide range of biological processes including nephrogenesis, gliogenesis, hepatogenesis, T cell proliferation, inflammation and oncogenesis. Many of these responses are triggered by the IL-6 family of cytokines, which transduce their vital signals through a common gp130 receptor chain . A novel Stat3-Interacting Protein, StIP1, contains 12 WD40 repeats, which mediate protein-protein interactions . StIP1 exhibits an affinity for members of the JNK family and may play a specific role in regulating Stat3 activation. Overexpression of StIP1 blocks Stat3 activation, nuclear translocation and Stat3-dependent induction of a reporter gene, suggesting that StIP1 regulates the ligand-dependent activation of Stat3, probably by serving as a scaffold protein that promotes the interaction between JNK and the Stat3 substrate.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

0.4 mg/mL

Unconjugated

IHC 1:100-1:300

Recombinant protein of human ELP2

Affinity purification

AU023723;Elongation protein 2 homolog (S. cerevisiae);Elongator acetyltransferase complex subunit 2;Elongator complex protein 2;elongator protein 2;ELP2;ELP2;Epl2;FLJ10879;SHINC 2;SHINC-2;SHINC2;signal transducer and activator of transcription 3 interacting protein 1;signal transducer and activator of transcription interacting protein 1;STAT3 interacting protein 1;Stat3 interacting protein;STAT3-interacting protein 1;STATIP 1;STATIP1;STATIP1 protein;StIP;StIP1

Q6IA86