E-Cadherin Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-31261-20uL | 20uL | £125.00 |
Quantity:
| E-AB-31261-60uL | 60uL | £172.00 |
Quantity:
| E-AB-31261-120uL | 120uL | £237.00 |
Quantity:
| E-AB-31261-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
E-cadherin
Background:
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
97kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
Immunogen:
Synthesized peptide derived from the N-terminal region of human E-cadherin
ObservedMW:
100kDa
Purification method:
Affinity purification
Target Synonym:
Arc 1;CADH1;Cadherin 1;cadherin 1 type 1 E-cadherin;Cadherin1;CAM 120/80;CD 324;CD324;CD324 antigen;cdh1;CDHE;E-Cad/CTF3;E-cadherin;ECAD;Epithelial cadherin;epithelial calcium dependant adhesion protein;LCAM;Liver cell adhesion molecule;UVO;Uvomorulin
UNIProt ID:
P12830
References
- https://europepmc.org/article/pmc/pmc8712759?javascript_support=no
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068511/
- https://www.nature.com/articles/srep33856
- https://www.hindawi.com/journals/cjgh/2022/5332129/
- https://www.spandidos-publications.com/10.3892/ol.2018.9251?text=abstract
- https://www.spandidos-publications.com/10.3892/mmr.2021.12471
- https://www.ncbi.nlm.nih.gov/pmc/articles/pmc8607078/