MKP-3 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-10308-20uL | 20uL | £125.00 |
Quantity:
| E-AB-10308-60uL | 60uL | £172.00 |
Quantity:
| E-AB-10308-120uL | 120uL | £237.00 |
Quantity:
| E-AB-10308-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
DUSP6
Background:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
27kDa
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant protein of human DUSP6
Purification method:
Affinity purification
Target Synonym:
Dual specificity phosphatase 6;Dual specificity phosphatase 6 isoform a;Dual specificity protein phosphatase 6;Dual specificity protein phosphatase PYST1;DUS6;DUSP 6;DUSP 6a;Dusp6;DUSP6a;HH19;MAP kinase phosphatase 3;Mitogen activated protein kinase phosphatase 3;Mitogen-activated protein kinase phosphatase 3;MKP 3;MKP-3;MKP3;PYST 1;PYST1;Serine/threonine specific protein phosphatase
UNIProt ID:
Q16828