DSP Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-15605-20uL | 20uL | £125.00 |
Quantity:
| E-AB-15605-60uL | 60uL | £172.00 |
Quantity:
| E-AB-15605-120uL | 120uL | £237.00 |
Quantity:
| E-AB-15605-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
DSP
Background:
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Synthetic peptide of human DSP
Purification method:
Affinity purification
Target Synonym:
250/210 kDa paraneoplastic pemphigus antigen;DCWHKTA;Desmoplakin (DPI DPII);Desmoplakin;Desmoplakin I;Desmoplakin II;DESP;DP;DP I;DP II;DPI;DPII;DSP;KPPS2;PPKS 2;PPKS2
UNIProt ID:
P15924