HSP40-4 Polyclonal Antibody
Code | Size | Price |
---|
E-AB-11313-20uL | 20uL | £125.00 |
Quantity:
E-AB-11313-60uL | 60uL | £172.00 |
Quantity:
E-AB-11313-120uL | 120uL | £237.00 |
Quantity:
E-AB-11313-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Images
Further Information
Abbreviation:
DNAJA1
Background:
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
45kDa
Concentration:
0.5 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300
Immunogen:
Recombinant protein of human DNAJA1
Purification method:
Affinity purification
Target Synonym:
DJ 2;DJ2;DjA1;DnaJ (Hsp40) homolog;subfamily A;member 1;DnaJ homolog subfamily A member 1;DnaJ protein homolog 2;DNAJ2;Dnaja1;DNJA1;hDJ 2;HDJ-2;HDJ2;Heat shock 40 kDa protein 4;heat shock protein DNAJ like 2;Heat shock protein J2;HSDJ;HSJ-2;HSJ2;HSPF4;Human DnaJ protein 2;NEDD7;Neural precursor cell expressed developmentally down regulated 7;OTTHUMP00000021193
UNIProt ID:
P31689