DLAT Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-17216-20uL | 20uL | £125.00 |
Quantity:
| E-AB-17216-60uL | 60uL | £172.00 |
Quantity:
| E-AB-17216-120uL | 120uL | £237.00 |
Quantity:
| E-AB-17216-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
DLAT
Background:
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
69 kDa
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:30-150, ELISA 1:2000-5000
Immunogen:
Fusion protein of human DLAT
Purification method:
Affinity purification
Target Synonym:
70 kDa mitochondrial autoantigen of primary biliary cirrhosis;Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex;Dihydrolipoamide S Acetyltransferase;Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex;dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial;DLAT;DLTA;E2;E2 component of pyruvate dehydrogenase complex;M2 antigen complex 70 kDa subunit;mitochondrial;ODP2;PBC;PDC E2;PDC-E2;PDCE2;Pyruvate dehydrogenase complex component E2;Pyruvate dehydrogenase complex E2 subunit
UNIProt ID:
P10515