DIO2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-13198-20uL | 20uL | £125.00 |
Quantity:
| E-AB-13198-60uL | 60uL | £172.00 |
Quantity:
| E-AB-13198-120uL | 120uL | £237.00 |
Quantity:
| E-AB-13198-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
DIO2
Background:
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.9 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:25-1:100
Immunogen:
Synthetic peptide of human DIO2
Purification method:
Affinity purification
Target Synonym:
5DII;D2;Deiodinase;iodothyronine;type II;DIO2;DIOII;EC 1.97.1.10;IOD2;ITDI2;SelY;Thyroxine deiodinase;type II;TXDI2;Type 2 DI;Type 2 iodothyronine deiodinase;Type II 5' deiodinase;Type II iodothyronine deiodinase;Type-II 5''-deiodinase
UNIProt ID:
Q92813
References
- https://www.frontiersin.org/articles/10.3389/fonc.2020.01771/full?report=reader