DEAF1 Polyclonal Antibody

DEAF1

Suppressin, also known as DEAF1 (deformed epidermal autoregulatory factor 1), SPN, NUDR (nuclear DEAF-1-related transcriptional regulator), or ZMYND5 (zinc finger MYND domain-containing protein 5), is a transcription factor required for embryonic development. Suppressin contains one SAND domain and one C-terminal MYND-type zinc finger. It interacts with LMO4 and CLIM-2, suggesting that it plays a role mediating cell fate and embryonic pattern formation. Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

1.4 mg/mL

Unconjugated

IHC 1:50-1:200

Synthetic peptide of human DEAF1

Affinity purification

Deaf1;DEAF1 transcription factor;DEAF1;Deformed epidermal autoregulatory factor 1 homolog;Nuclear DEA1 related transcriptional regulator;Nuclear DEAF-1-related transcriptional regulator;NUDR;SPN;Suppressin;Zinc finger MYND domain containing protein 5;Zinc finger MYND domain-containing protein 5;ZMYND5

O75398