DDIT4 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-11148-20uL | 20uL | £125.00 |
Quantity:
| E-AB-11148-60uL | 60uL | £172.00 |
Quantity:
| E-AB-11148-120uL | 120uL | £237.00 |
Quantity:
| E-AB-11148-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
DDIT4
Background:
REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thought to function in the regulation of reactive oxygen species (ROS). REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level. REDD-1 negatively regulates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP. It is crucial in the coupling of extra- and intracellular cues to FRAP regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.8 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Recombinant protein of human DDIT4
Purification method:
Affinity purification
Target Synonym:
DDIT4;DDIT4;Dig2;DNA damage inducible transcript 4;DNA damage inducible transcript 4 protein;DNA damage-inducible transcript 4 protein;FLJ20500;HIF 1 responsive protein RTP801;HIF 1 responsive RTP801;HIF-1 responsive protein RTP801;Protein regulated in development and DNA damage response 1;REDD-1;REDD1;RTP801
UNIProt ID:
Q9NX09