DCC Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-15932-20uL | 20uL | £125.00 |
Quantity:
| E-AB-15932-60uL | 60uL | £172.00 |
Quantity:
| E-AB-15932-120uL | 120uL | £237.00 |
Quantity:
| E-AB-15932-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
DCC
Background:
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.7 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Synthetic peptide of human DCC
Purification method:
Affinity purification
Target Synonym:
Colorectal cancer related chromosome sequence 18;Colorectal cancer suppressor;CRC 18;CRC18;CRCR 1;CRCR1;DCC;DCC;Deleted in colorectal cancer protein;Deleted in colorectal carcinoma;Immunoglobulin superfamily DCC subclass member 1;Netrin receptor DCC;Tumor suppressor protein DCC
UNIProt ID:
P43146